Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial

Table 2 Spearman correlation co-efficients associated with soft tissue response for each of the variables

Variable	Biomarker	Spearman correlation co-efficient	P value (not corrected)
Level of biomarker at baseline	Trap5b	0.45	0.007
Level of biomarker at 6 weeks	Trap5b	0.5	0.002
Level of biomarker at time of best response or earlier	IGF-II	−0.4	0.02
	BoneAP	0.46	0.006
	Trapb5	0.47	0.006
Change in biomarker from baseline to 6 weeks	None
Change in biomarker from baseline to best response or earlier	TIMP2	0.41	0.02

ISSN: 1479-5876