Table 2 Univariate Kaplan–Meier (KM) and Cox proportional hazards (PH) models and multivariate Cox PH models for the 21 Chinese HCC patients in this study, HCC patients from Roessler et al. study, and HCC patients from Boyault et al. study

Univariate Cox PH

 HBV pre-OLT (Yes, No)

0.285 (0.06, 1.48)

0.14

 Tumor grade (GI, GII GIII)

1.27 (0.63, 2.01)

4.50E−02

 Age (<49)

2.33 (0.62, 8.68)

0.21

 Gender (M, F)

0.29 (0.03, 2.47)

0.26

 HERC5 (Low, High)

10.34 (1.28, 83.55)

0.029

Univariate KM

 HERC5 (Low, High)

0.007

Multivariate Cox PH

 HERC5 (Low)

7.29

0.07

 HBV pre-OLT (Yes, No)

0.26

0.3

 Tumor grade

2.41

0.27

 Age (<49)

2.08

0.42

 Gender (M, F)

1.86

0.7

Univariate Cox PH

 HBV (AVR-CC, CC, No)

1.32 (0.86, 2.03)

0.212

1.24 (0.86, 1.79)

0.26

 TNM Staging (I, II, III)

2.34 (1.77, 3.09)

2.18E−09

1.76 (1.41, 2.20)

7.81E−07

 Age (<50)

1.26 (0.84, 1.88)

0.262

1.01 (0.72, 1.42)

0.96

 Gender (M, F)

1.86 (0.09, 3.83)

0.0933

2.36 (1.24, 4.50)

0.009

 Cirrhosis (No, Yes)

0.20 (0.05, 0.80)

0.0227

0.50 (0.23, 1.07)

0.07

 HERC5 (Low, High)

1.79 (1.17, 2.74)

0.00706

1.55 (1.07, 2.24)

0.021

Univariate KM

 HERC5 (Low, High)

0.0063

0.0198

Multivariate Cox PH

 HERC5 (Low)

2.02

0.004

1.8

0.004

 Gender (M, F)

1.36

0.42

2.07

0.03

 Cirrhosis (No, Yes)

0.28

0.076

0.56

0.17

 Age (<50)

1

0.99

1.01

0.49

 HBV (AVR-CC, CC, No)

1.3

0.25

1.36

0.11

 TNM Staging (I, II, III)

2.32

1.06E−08

1.74

2.21E−06

Univariate Cox PH

 HBV (Yes, No)

1.32 (0.51, 3.40)

0.57

1.02 (0.44, 2.38)

0.96

 Gender (M, F)

1.01 (0.34, 3.03)

9.88E−01

1.30 (0.49, 3.41)

6.01E−01

 Age (<65)

1.10 (0.45, 2.67)

0.85

1.48 (0.70, 3.17)

0.31

 HERC5 (Low, High)

2.69 (1.11, 6.51)

0.029

1.96 (0.95, 4.05)

0.07

Univariate KM

 HERC5 (Low, High)

0.023

0.07

Multivariate Cox PH

 HERC5 (Low)

3.31

0.018

3.8

0.01

 HBV (Yes, No)

1.28

0.63

1.16

0.78

 Gender (M, F)

1.22

0.74

1.32

0.64

 Age (<65)

1.02

0.42

1.02

0.4