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Table 1 The summary of clinical information for 21 Chinese HCC patients

From: HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma

Patient

Recurrent with 24 months±

Sex

Age

Primary tumor grade

Child

BCLC

Primary tumor size (cm)

Criteria (Milan = 1; UCSF = 2; Exceed = 3)

AFP (ng/mL)

MELD

Time of recurrent after OLT (month)

Recurrent tumor organ

HBV (pre-OLT)

HBV (post-OLT)

MULT±

SAT±

ENCAP±

CIRR±

VES±

THROMB±

HCC1*

1

M

48

III

A

A3

5*5*3

1

2935.9

8

8

Liver

Positive

Negative

0

0

0

1

0

1

HCC4*

1

M

59

II

A

B

8*6*5.5

3

2.5

5

6.5

Liver

Positive

Positive

1

1

1

0

0

0

HCC5*

1

M

67

II

A

B

5*4*3

1

>3000

2

18

Liver

Negative

Negative

1

0

0

1

0

1

HCC11*

1

F

57

II–III

A

B

0.5–2.5

1

1581.6

2

16

Lung

Negative

Negative

1

0

0

1

0

0

HCC2

1

M

43

II

A

B

9*8*6

3

1461.1

21

19

Liver

Positive

Negative

0

1

N/A

1

0

0

HCC3

1

M

42

III

B

B

6*6*2.5, 10*8*4

3

>3000

5

14.5

Liver

Positive

Negative

1

0

0

1

0

1

HCC6

1

M

41

III

A

B

7*5*4

3

126

4

1.5

Lung

Positive

Negative

0

0

0

1

0

0

HCC8

1

M

42

III

A

B

10*10*7

3

>3000

5

11

Liver

Positive

Negative

0

1

0

1

N/A

1

HCC10

1

M

59

III

A

A3

4*3.5*3.5

1

1888.2

15

6

Liver

Positive

Negative

0

0

0

1

0

1

HCC-C2

0

M

55

I–II

C

D

5.5*5*4.5*

2

5.2

4

N/A

N/A

Positive

Negative

0

0

0

1

0

0

HCC-C6

0

M

51

II

B

A3

3*2.5*2*

1

137.5

13

N/A

N/A

Positive

Negative

0

0

0

1

0

0

HCC-C8

0

M

64

I

B

A3

5*1.5*1.5*, 3*2*2*

3

62.5

13

N/A

N/A

Positive

Positive

1

0

0

1

0

0

HCC-C9

0

M

40

II

B

A3

1*1*1*

1

9.2

3

N/A

N/A

Positive

N/A

0

0

0

1

0

0

HCC-C11

0

M

62

I

A

A3

3*3*2*

1

5.4

9

N/A

N/A

Positive

Negative

0

0

0

1

0

0

HCC-C12

0

M

40

II–III

A

A2

2.5*1.5*1*

1

210.8

4

N/A

N/A

Positive

Positive

0

0

0

1

0

0

HCC-C13

0

M

49

I–II

A

C

3*2.5*2.5*; 2*2*2*

1

4.3

4

N/A

N/A

Positive

Negative

1

0

0

1

1

0

HCC-C14

0

M

59

II

B

B

7*5*5*

3

240.7

20

N/A

N/A

Positive

N/A

0

0

0

1

0

0

HCC-C15

0

M

49

II

A

B

5*4*2*; 5*4.5*3*

3

NA

4

N/A

N/A

Positive

Negative

0

1

0

1

0

0

HCC-C16

0

M

49

II–III

B

A3

5*5*4*

1

128.9

11

N/A

N/A

Positive

N/A

0

1

0

1

0

0

HCC-C18

0

M

57

I

A

A2

5*4*4*

1

6.6

2

N/A

N/A

Positive

Negative

0

0

0

1

0

0

HCC-C19

0

M

41

II–III

A

B

4*2.5*2*, 3*2*1.8*

2

220.9

2

N/A

N/A

Positive

Positive

1

0

0

1

0

0

  1. Patient OLT inclusion criteria included: ECOG (Eastern Cooperative Oncology Group performance status) score 0–2, tumor within Hangzhou criteria and no major vascular invasion or extra hepatic metastases from imaging studies. Exclusion criteria included absolute contradictions of: involvement of the surrounding tissue or distant metastasis, co-current non-curable extra hepatic malignancies, active infection; relative contraindications included: pulmonary hypertension, symptomatic ischemic heart disease, severe renal insufficiency, and mental disorders
  2. AFP alpha-fetoprotein, HBV hepatitis B virus, MULT multiplicity, ENCAP encapsulated, CIRR cirrhosis, THROMB thrombosis, OLT orthotopic liver transplantation, BCLC barcelona Clinical Liver Cancer staging, SAT satellite, VES vessel, Child Child-Pugh score, MELD Model for End-Stage Liver Disease, ±1 Yes, 0 No
  3. * These 4 patients have matched primary and recurrent tumor specimens, normal adjacent tissue from the primary and recurrent tumors, and recipient blood specimens (n = 20 total specimens)
  4. Italicized rows indicate patients who did not experience tumor recurrence post-OLT (n = 12), while non-italicized rows indicate patients who did experience tumor recurrence post-OLT (n = 9)