Table 2 Multivariate analysis of prognostic factors in the patients with nasopharyngeal carcinoma (N = 694)
Variable | DMFS | OS | PFS | |||
|---|---|---|---|---|---|---|
P value | HR (95 % CI) | P value | HR (95 % CI) | P value | HR (95 % CI) | |
Age (≥50 vs. <50 years) | ||||||
Sex (male vs. female) | ||||||
T classification (T3–4 vs. T1–2) | 0.051 | 1.392 (0.998–1.942) | 0.028 | 1.410 (1.038–1.915) | ||
N classification (N1–3 vs. N0) | 0.005 | 1.903 (1.215–2.982) | 0.054 | 1.439 (0.994–2.085) | 0.005 | 1.663 (1.165–2.374) |
Chemotherapy (yes vs. no) | ||||||
White blood cell count (≥6.9 vs. <6.9 k/μL) | ||||||
NLR (≥2.3 vs. <2.3) | ||||||
Blood platelet count (≥221 vs. <221 k/μL) | 0.078 | 1.373 (0.965–1.954) | ||||
PLR (≥120.7 vs. <120.7) | ||||||
Hemoglobin (<144 vs. ≥144 g/L) | ||||||
PNI (<55.0 vs. ≥55.0) | 0.011 | 1.603 (1.116–2.303) | 0.012 | 1.501 (1.095–2.058) | 0.012 | 1.460 (1.088–1.961) |
Alkaline phosphatase (≥68 vs. <68 U/L) | 0.002 | 1.773 (1.233–2.549) | 0.003 | 1.626 (1.177–2.247) | <0.001 | 1.711 (1.266–2.313) |
Bilirubin (≥4.1 vs. <4.1 μmol/L) | ||||||
Globulin (≥30.2 vs. <30.2 g/L) | 0.032 | 1.485 (1.034–2.134) | 0.041 | 1.396 (1.013–1.924) | ||
Body mass index | 0.017 | |||||
Underweight (<18.5 kg/m2) | 0.008 | 2.060 (1.212–3.501) | ||||
Normal weight (18.5–22.99 kg/m2) | 1 | |||||
Overweight (23.0–27.49 kg/m2) | 0.297 | 1.230 (0.834–1.812) | ||||
Obese (≥27.5 kg/m2) | 0.185 | 0.534 (0.211–1.351) | ||||
Weight loss, % | 0.038 | 0.002 | ||||
LWL (less than 5.0 %) | 1 | 1 | ||||
MWL (5.0–9.99 %) | 0.343 | 1.243 (0.792–1.950) | 0.082 | 1.437 (0.955–2.161) | ||
HWL (10 % or more) | 0.014 | 1.787 (1.127–2.834) | 0.001 | 2.053 (1.362–3.095) | ||