Fig. 5

Effects of FLP ointment on VEGF and PDGFRβ expression in the lung tissues. a Immunohistochemical analysis of VEGF and PDGFRβ expression (×200 magnification and ×100 magnification). The brown or brown yellow represented positive VEGF and PDGFRβ protein. b A representative band of VEGF and PDGFRβ protein expression by Western blot analysis. c Relative protein level of VEGF and PDGFRβ (n = 3). Values were expressed as mean ± SD. **p < 0.01, *p < 0.05, ***p < 0.001, and ****p < 0.0001. FLP Fei-Liu-Ping ointment group, C celecoxib group, FLP + C Fei-Liu-Ping ointment plus celecoxib group. FLP ointment in combination with celecoxib inhibited VEGF and PDGFRβ protein expression in the lung metastatic inflammatory microenvironment