Fig. 3

Effects of FLP ointment on histological changes and mPGES-1 expression in the lung tissues. a Histological analysis of the lung tissues in Lewis lung carcinoma xenograft mice. Large number of inflammatory cell infiltration was found in the alveolar septum around the metastasis location in the control group, while inflammatory cell infiltration was alleviated in the treatment group. b Immunohistochemical analysis of mPGES-1 expression in lung tissues (×200 magnification and ×100 magnification). The brown or brown yellow represented positive mPGES-1 protein. c A representative band of mPGES-1 protein expression by Western blot analysis. d Relative protein level of mPGES-1 (n = 3). Values were expressed as mean ± SD. **p < 0.01, *p < 0.05, ***p < 0.001, and ****p < 0.0001. FLP Fei-Liu-Ping ointment group, C celecoxib group, FLP + C Fei-Liu-Ping ointment plus celecoxib group. FLP ointment in combination with celecoxib exerted a synergistic effect in inhibiting mPGES-1 expression