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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules

Fig. 4

β-Elemene regulated the expression of stemness markers and differentiation-related effectors in glioblastoma cells. a CD133+ and ABCG2+ cells were sparsely distributed throughout both G1 and G2 tissues, and both CD133 and ABCG2 were localized to both the cytoplasm and cytomembrane. The expression of GFAP was higher in the G1 tissue than in the G2 tissue. b β-Elemene decreased the expression levels of CD133 and ABCG2 and increased the expression levels of GFAP, Notch1 and SHH in a dose-dependent manner. c The results of (b) were semi-quantitatively estimated using Gel-Pro Analyzer 4.0 software and are illustrated graphically. The results are representative of three independent experiments, and the values are presented as the mean ± SD (*p < 0.05, **p < 0.01)

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Journal of Translational Medicine

ISSN: 1479-5876

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