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Table 1 Selected list of genes regulating neutrophil function

From: Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies

Gene Role(s) in neutrophil homeostasis
CD177 NB1 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed exclusively by neutrophils, metamyelocytes and myelocytes
SOD1 The SOD1 gene encodes superoxide dismutase-1, a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide. CD177 is upregulated in various inflammatory settings, including bacterial infections. Heterophilic PECAM1/CD177 interactions affect the phosphorylation state of PECAM1, as well as endothelial junction integrity and neutrophil transmigration
CD64 CD64 is the gene encoding human FcγRI (FCGR1), a glycoprotein that is constitutively expressed on human monocytes and macrophages and that plays a pivotal role in the immune response
FCGR3B The Fc receptor with low affinity for IgG (CD16b) encodes a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed constitutively by neutrophils
ELANE Neutrophil elastase is a serine protease of neutrophil and monocyte granules, with key physiologic roles in innate host defense
MPO Myeloperoxidase is a lysosomal protein located in the azurophilic granules of polymorphonuclear leukocytes and monocytes. MPO is responsible for microbicidal activity against a wide range of organisms
LYZ Lysozyme catalyzes the hydrolysis of certain mucopolysaccharides of bacterial cell walls
CEACAM8 (CD67) Neutrophil surface protein that is attached to the membrane via a glycosylphosphatidylinositol anchor. In neutrophils, the CEACAM8 gene is primarily detected in the secondary cytoplasmic granules, but it can also be found in lower amounts on the plasma membrane. The amount of surface CD67 is upregulated upon granulocyte activation
CD62L Homing receptor for lymphocytes to enter secondary lymphoid tissues via high endothelial venules
  1. Based on current knowledge, a panel of genes was selected that have been shown to contribute to neutrophil function in health and/or disease states. A brief description of the main function of each gene product in neutrophil homeostasis is provided