Table 1 Selected list of genes regulating neutrophil function

CD177

NB1 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed exclusively by neutrophils, metamyelocytes and myelocytes

SOD1

The SOD1 gene encodes superoxide dismutase-1, a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide. CD177 is upregulated in various inflammatory settings, including bacterial infections. Heterophilic PECAM1/CD177 interactions affect the phosphorylation state of PECAM1, as well as endothelial junction integrity and neutrophil transmigration

CD64

CD64 is the gene encoding human FcγRI (FCGR1), a glycoprotein that is constitutively expressed on human monocytes and macrophages and that plays a pivotal role in the immune response

FCGR3B

The Fc receptor with low affinity for IgG (CD16b) encodes a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed constitutively by neutrophils

ELANE

Neutrophil elastase is a serine protease of neutrophil and monocyte granules, with key physiologic roles in innate host defense

MPO

Myeloperoxidase is a lysosomal protein located in the azurophilic granules of polymorphonuclear leukocytes and monocytes. MPO is responsible for microbicidal activity against a wide range of organisms

LYZ

Lysozyme catalyzes the hydrolysis of certain mucopolysaccharides of bacterial cell walls

CEACAM8 (CD67)

Neutrophil surface protein that is attached to the membrane via a glycosylphosphatidylinositol anchor. In neutrophils, the CEACAM8 gene is primarily detected in the secondary cytoplasmic granules, but it can also be found in lower amounts on the plasma membrane. The amount of surface CD67 is upregulated upon granulocyte activation

CD62L

Homing receptor for lymphocytes to enter secondary lymphoid tissues via high endothelial venules