Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin

Table 3 Univariate and multivariate analyses of the survival of HCC patients

Covariate	n	Univariate analysis			Multivariate analysis
Covariate	n	HR	95 % CI	P value	HR	95 % CI	P value
Gender				0.710			0.758
Male	48	1.000			1.000
Female	6	1.254	0.381–4.126		1.232	0.326–4.654
Age (years)				0.812			0.371
≤50	17	1.000			1.000
>50	37	1.099	0.506–2.387		0.671	0.280–1.609
Tumor size (cm)				0.037			0.062
≤5	27	1.000			1.000
>5	27	2.170	1.046–4.504		2.148	0.964	4.785
TNM stage				0.105			0.329
I	6	1.000			1.000
II	37	1.087	0.323–3.659
III	11	2.395	0.633–9.058		1.459	0.683–3.116
Cytoplasmic PRMT5				0.033			0.029
Low	36	1.000			1.000
High	18	2.175	1.067–4.435		2.411	1.094–5.313
Nuclear PRMT5				0.963			0.691
Low	40	1.000			1.000
High	14	1.020	0.439–2.369		1.228	0.446–3.380

The Cox proportional hazards regression model was used for univariate and multivariate analyses to study the effects of the clinicopathological variables and PRMT5 expression on survival
HR hazard ratio, CI confidence interval

ISSN: 1479-5876