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Table 3 Univariate and multivariate analyses of the survival of HCC patients

From: Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin

Covariate n Univariate analysis Multivariate analysis
HR 95 % CI P value HR 95 % CI P value
Gender     0.710    0.758
 Male 48 1.000    1.000   
 Female 6 1.254 0.381–4.126   1.232 0.326–4.654  
Age (years)     0.812    0.371
 ≤50 17 1.000    1.000   
 >50 37 1.099 0.506–2.387   0.671 0.280–1.609  
Tumor size (cm)     0.037    0.062
 ≤5 27 1.000    1.000   
 >5 27 2.170 1.046–4.504   2.148 0.964 4.785
TNM stage     0.105    0.329
 I 6 1.000    1.000   
 II 37 1.087 0.323–3.659     
 III 11 2.395 0.633–9.058   1.459 0.683–3.116  
Cytoplasmic PRMT5     0.033    0.029
 Low 36 1.000    1.000   
 High 18 2.175 1.067–4.435   2.411 1.094–5.313  
Nuclear PRMT5     0.963    0.691
 Low 40 1.000    1.000   
 High 14 1.020 0.439–2.369   1.228 0.446–3.380  
  1. The Cox proportional hazards regression model was used for univariate and multivariate analyses to study the effects of the clinicopathological variables and PRMT5 expression on survival
  2. HR hazard ratio, CI confidence interval