Fig. 2
From: Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS
The percentages of activated CD4+ T-lymphocytes (a) and/or CD8+ T-lymphocytes (b) among treated and untreated cell aliquots. A significant increase in the number of activated T-lymphocytes was observed in the whole blood from patients with MS compared to in whole blood from healthy subjects following an overnight incubation with MBP. In comparison, samples from healthy subjects exhibited significantly fewer activated T-lymphocytes following incubation with the different MBPs. (*significantly different, p < 0.01). HC-without: blood from healthy controls (HC) without proteins/peptides added; MS-without: blood from MS patients without proteins/peptides added. HC-with total huMBP, huMBP104–1184, gpMBP68–82: blood from HC incubated with human MBP, human MBP104–118 peptide and/or guinea pig MBP 68–82. MS-with total huMBP, huMBP104–118, gpMBP68–82: blood from MS patients incubated with human MBP, human MBP104–118 peptide and/or guinea pig MBP 68–82