Fig. 1

Correlation between blood parameters and signal molecules in diabetic rats. The rat model of diabetes was established by intraperitoneal injection of 65 mg/kg STZ. On week 0, 4, 8, 12, 16, a Serum creatinine and b blood urea nitrogen (BUN) were measured, and c renal tubule miR-29 level was determined using quantitative RT-PCR. Correlated analysis was performed to assess relationship between d miR-29 level and Serum creatinine as well as e miR-29 level and creatinine clearance. f Sirt1 activity was assessed. g Western blotting was performed to determine expressions of Keap1 and nuclear Nrf2 in isolated renal tubules. Data were presented as mean ± SD. **P < 0.01 vs. normal rats