Fig. 3

Virus neutralization titers in sera from immunized cotton rats. a Representative data from plaque reduction assays of pooled sera obtained at 49 days post immunization and used to determine neutralization titers. Arrow indicates titer for VLP-low dose. b RSV A2 neutralization titers with time in pooled sera. Data are the average of five separate determinations by the method shown in a. Arrow indicates time of the boost immunization. RSV A2 neutralization titers in sera from individual cotton rats at day 35 (c) and day 49 (d) post immunization, determined as shown in a. Immunogens are shown at the bottom of the panels. Differences between the RSV group and the VLP groups are significant (p = 0.0012 and p = 0.019, respectively). Differences between the two VLP groups are not significant