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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway

Fig. 6

Signaling pathways involved in the inhibition of EMT by CHBP. CHBP stimulates the PI3 K/Akt signaling pathway to phosphorylate FoxO3a, leading to cytoplasmic sequestration of the transcription factor and inactivation of transcriptional activity. The absence of FoxO3a transcriptional activity results in decreased EMT-associated gene expression. Wortmannin can also inhibit PI3 K activity

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