Fig. 6

Signaling pathways involved in the inhibition of EMT by CHBP. CHBP stimulates the PI3 K/Akt signaling pathway to phosphorylate FoxO3a, leading to cytoplasmic sequestration of the transcription factor and inactivation of transcriptional activity. The absence of FoxO3a transcriptional activity results in decreased EMT-associated gene expression. Wortmannin can also inhibit PI3 K activity