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Table 1 Characteristics of DCIS found in BRCA mutation carriers with invasive tumors and concurrent DCIS

From: DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C-MET and HER3

 

BRCA1

BRCA2

P-value

N (%)

N (%)

% DCIS

  

0.14

 <15 %

15 (53.6 %)

8 (32.0 %)

 

 15–49 %

9 (32.1 %)

8 (32.0 %)

 

 50+%

4 (14.3 %)

9 (36.0 %)

 

DCIS morphology

  

0.10

 Solid

4 (11.4 %)

3 (10.7 %)

 

 Cribriform

9 (25.7 %)

14 (50.0 %)

 

 Comedo

19 (52.3 %)

7 (25.0 %)

 

 Complex

3 (8.6 %)

4 (14.3 %)

 

DCIS Distance from IBC

  

0.31

 Intermixed

12 (42.9 %)

14 (56.0 %)

 

 Peripheral (<2 mm from IBC)

14 (50.0 %)

11 (44.0 %)

 

 Distant (>2 mm from IBC)

2 (7.1 %)

0 (0 %)

 

DCIS Grade

0.63

 Low

2 (5.7 %)

1 (3.6 %)

 

 Intermediate

11 (31.4 %)

12 (42.9 %)

 

 High

22 (68.9 %)

15 (53.6 %)

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