Kidney no | Perfusion grade | EVNP score | Remuzzi score | ATI |
|---|
Score 1 and 2 |
2 | 1 | 1 | 9 | None |
3 | 4 | 2 | 6 | Moderate |
5 | 4 | 2 | 4 | Mild |
6 | 2 | 2 | 3 | Mild |
7 | 1 | 1 | 7 | None |
11 | 1 | 2 | 10 | None |
12 | 4 | 1 | 6 | Milda
|
14 | 1 | 2 | 4 | Mild to moderate |
15 | 4 | 1 | 5 | Mild to moderateb
|
17 | 1 | 2 | – | – |
18 | 1 | 2 | 0 | Mild |
21 | 3 | 2 | 3 | Mild |
Score 3 and 4 |
4 | 4 | 4 | 2 | None |
8 | 2 | 3 | 3 | Mild |
9 | 2 | 3 | 1 | Mild |
16 | 4 | 3 | 6 | None |
19 | 1 | 3 | 2 | Mild |
20 | 4 | 3 | 5 | Mild |
22 | 3 | 3 | – | Moderate |
Score 5 | | | | |
1 | 1 | 5 | 0 | Nonea
|
10 | 3 | 5 | – | Severe |
13 | 3 | 5 | 6 | Nonec
|
- A wedge biopsy was taken on arrival at the laboratory after the period of static cold storage. The tissue was fixed in 10 % formal saline then embedded in paraffin wax. Sections from the paraffin embedded tissue were cut (4 µm) and stained with H&E for histopathological scoring. Sections were assessed using the Remuzzi score by a consultant pathologist who was blinded to the donor types. Four different parameters were assessed in the scoring system; Glomerular global sclerosis, tubular atrophy, interstitial fibrosis and vascular lesions (8). The score ranged from a minimum of 0 (indicating the absence of renal lesions) to 3 (severe). The sum of the four parameters was then calculated. A score of 0–3 indicated mild changes, 4–6 moderate and 7–12 severe. Sections were graded mild, moderate and severe for the presence of acute tubular injury. Pairs of kidneys; (8, 9), (11, 12), (15, 16), (17, 18), (19, 20) and (21, 22)
-
aVacuolation of the proximal tubular epithelial cells
-
bGlomerular capillary thrombi
-
cGlomerular capillary thrombi and early cortical necrosis
