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Table 4 Liver expression of genes related to lipid metabolism

From: Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

Protein

Gene

Hz vs. WT (fold change)

p value

Hz + IGF vs. Hz (fold change)

p value

Acetyl-Coenzyme A acyltransferase 1B

(Acaa1b)

−4.04

0.002

2.28

0.00012

Acetyl-Coenzyme A acetyltransferase 1

(Acat1)

−1.62

0.00006

1.21

0.017

Acetyl-Coenzyme A acetyltransferase 2

(Acat2)

−1.50

0.04

1.34

0.02

Acyl-Coenzyme A oxidase 1, palmitoyl

(Acox1)

−1.70

0.004

1.14

0.13

Acyl-CoA synthetase long-chain family member 1

(Acsl1)

−2.20

0.0001

1.85

0.011

Acyl-CoA synthetase long-chain family member 3

(Acsl3)

−1.96

0.018

−1.06

0.19

Acyl-CoA synthetase medium-chain family m2

(Acsm2)

−1.09

0.57

1.50

0.002

Acyl-CoA thioesterase 9

(Acot9)

1.77

0.008

−1.70

0.006

Cytochrome b5 reductase 3

(Cyb5r3)

−1.52

0.04

1.46

0.03

Phenylalkylamine Ca2+ antagonist (emopamil) binding protein

(Ebp)

1.49

0.13

−1.16

0.21

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

(Hmgcr)

−2.77

0.0018

1.37

0.003

3-hydroxy-3-methylglutaryl-Coenzyme A synthase1

(Hmgcs1)

−1.49

0.019

1.45

0.04

Isopentenyl-diphosphate delta isomerase

(Idi1)

−1.49

0.013

1.38

0.02

Mevalonate (diphospho) decarboxylase

(Mvd)

−2.13

0.002

1.69

0.01

ATP-binding cassette, sub-family G (WHITE), member 1

(Abcg1)

1.83

0.004

−1.66

0.05

Aldo–keto reductase family 1, member D1

(Akr1d1)

−2.36

0.0002

1.21

0.018

Cytochrome P450, family 46, subfamily a, polypeptide 1

(Cyp46a1)

−1.77

0.004

1.01

0.17

Cytochrome P450, family 7, subfamily a, polypeptide 1

(Cyp7a1)

−2.76

0.0002

1.54

0.0013

Very low density lipoprotein receptor

(Vldlr)

−3.12

0.0002

1.20

0.02

Low density lipoprotein receptor-related protein 1

(Lrp1)

−1.49

0.0004

1.13

0.58

Proprotein convertase subtilisin/kexin type 9

(Pcsk9)

−1.59

0.03

1.45

0.03

Fatty acid binding protein 1, liver

(Fabp1)

−1.53

0.03

1.50

0.007

Fatty acid binding protein 5, epidermal

(Fabp5)

5.06

0.0002

−2.27

0.006

Lipoprotein lipase

(Lpl)

2.02

0.0012

−2.50

0.002

  1. Control group, WT mice; Hz group including untreated mice with partial IGF-1 deficiency; Hz + IGF-1 group: Hz mice treated with low doses of IGF-1 during 10 days. Underlined values correspond to those with a fold-change >1.5, considered as a significant variation in the gene expression
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Journal of Translational Medicine

ISSN: 1479-5876

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