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Table 2 Liver expression of genes related to IGF-1

From: Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

Protein

Gene

Hz vs. WT (fold change)

p value

Hz + IGF vs. Hz (fold change)

p value

Insulin-like growth factor 1

(Igf1)

−2.48

0.0017

1.64

0.002

Insulin-like growth factor 2

(Igf2)

−1.35

0.14

1.48

0.16

Insulin-like growth factor binding protein 1

(Igfbp1)

−4.53

0.0001

−2.2

0.0012

Insulin-like growth factor binding protein 2

(Igfbp2)

−1.18

0.015

−1.02

0.37

Insulin-like growth factor binding protein 3

(Igfbp3)

−1.78

0.012

1.33

0.011

Insulin-like growth factor binding protein 4

(Igfbp4)

1.13

0.33

1.35

0.29

Insulin-like growth factor binding protein 5

(Igfbp5)

−1.37

0.10

1.37

0.17

Insulin-like growth factor binding protein 6

(Igfbp6)

−1.10

0.31

1.19

0.12

Albumin

(Alb)

−1.06

0.12

−1.01

0.14

Parvalbumin

(Pvalb)

−1.04

0.11

−1.10

0.13

Lactalbumin, alpha

(Lalba)

−1.10

0.14

1.04

0.12

D site albumin promoter binding protein

(Dbp)

2.33

0.05

−1.16

0.19

  1. Control group, WT mice; Hz group including untreated mice with partial IGF-1 deficiency; Hz + IGF-1 group: Hz mice treated with low doses of IGF-1 during 10 days. Underlined values correspond to those with a fold-change >1.5, considered as a significant variation in the gene expression