Fig. 4

Slower progression or alleviation of retinal lesions in the anti-LRP6 treated eyes as compared to the control in both models. a Representative fundoscopic images of Ccl2 ^−/− /Cx3cr1 ^−/− /rd8. Arrows indicate the yellowish deep retinal lesions. b Comparison of the average retinal lesion scores between treated and untreated eyes of 35 Ccl2 ^−/− /Cx3cr1 ^−/− /rd8 mice. Error bar mean ± SEM; *: p < 0.01. c Representative fundoscopic images of Ccl2 ^−/− /Cx3cr1 ^gfp/gfp. Arrows indicate the yellowish deep retinal lesions. In Ccl2 ^−/− /Cx3cr1 ^gfp/gfp, only 5 out of 10 treated eyes but 7 out of 10 control eyes showed lesion progression