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Table 3 Surface areas of significantly reduced CT in ACLF post-recovery over control and increased CT in post-recovery over baseline from both hemispheres

From: Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

Cluster No. Structures in area Max t statistic Size (mm2) TalX TalY TalZ Thickness (mm), mean ± SD
Control Post ACLF
1 L Posterior cingulate 5.392 79 −5.8 −13.9 39.2 2.77 ± 0.19 2.63 ± 0.16
2 L Middle temporal 4.887 196 −45.6 3.8 −34.3 3.27 ± 0.23 2.99 ± 0.21
3 L Superior frontal 4.768 62 −11 14 45.6 2.59 ± 0.16 2.54 ± 0.23
1 R Paracentral 5.153 166 10.1 −15.5 48.9 2.44 ± 0.12 2.42 ± 0.21
2 R Parahippocampal 4.928 59 25.2 −20.9 −27.3 3.20 ± 0.31 3.03 ± 0.22
3 R Lateral orbitofrontal 4.671 50 30.4 28.9 −2.4 2.72 ± 0.12 2.62 ± 0.23
4 R Posterior cingulate 3.926 17 5.1 −12.5 39.4 2.65 ± 0.13 2.64 ± 0.24
Cluster no. Structures in area Max t statistic Size (mm2) TalX TalY TalZ Thickness (mm), mean ± SD
Baseline ACLF Post ACLF
1 L Lateral orbitofrontal −2.745 577 −29 50.8 −10.9 2.08 ± 0.15 2.33 ± 0.15
2 L Rostral middle frontal −2.632 93 −37.1 43.4 0.3 1.95 ± 0.12 2.12 ± 0.11
3 L Rostral middle frontal −2.244 25 −38.6 26.5 35.6 2.25 ± 0.10 2.35 ± 0.09
4 L Rostral middle frontal −2.210 43 −33.9 32.4 29.5 2.06 ± 0.12 2.24 ± 0.14
5 L Superior frontal −2.204 59 −8.1 62.2 16.9 2.25 ± 0.16 2.50 ± 0.17
6 L Lateral orbitofrontal −2.013 4 −35.9 25.6 −17.7 2.31 ± 0.18 2.51 ± 0.12
1 R Entorhinal −3.97 185 21 −11.2 −29.2 2.89 ± 0.22 3.37 ± 0.22
2 R Superior frontal −2.313 71 8.3 58.1 26.5 2.29 ± 0.18 2.53 ± 0.15
3 R Rostral middle frontal −2.232 74 19.7 57 17.6 2.06 ± 0.21 2.30 ± 0.12
4 R Lateral orbitofrontal −2.086 36 17.1 39.4 −18.9 2.04 ± 0.14 2.26 ± 0.20
5 R Pars triangularis −2.0108 2 54.3 25.6 10.1 2.30 ± 0.14 2.50 ± 0.17
  1. Each area consists of adjacent voxels showing a significant group difference; some brain structures have more than one area of change. The magnitude of the peak (t statistic) in each area and its Tailarach coordinates (a standardized common brain space) are listed, together with the size (in normalized space) and the mean and SD of the cortical thickness for control and post recovery ACLF group. And baseline and post recovery ACLF group
  2. CT cortical thickness, L left, R right