Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

Table 3 Surface areas of significantly reduced CT in ACLF post-recovery over control and increased CT in post-recovery over baseline from both hemispheres

Cluster No.		Structures in area	Max t statistic	Size (mm²)	TalX	TalY	TalZ	Thickness (mm), mean ± SD
Cluster No.		Structures in area	Max t statistic	Size (mm²)	TalX	TalY	TalZ	Control	Post ACLF
1	L	Posterior cingulate	5.392	79	−5.8	−13.9	39.2	2.77 ± 0.19	2.63 ± 0.16
2	L	Middle temporal	4.887	196	−45.6	3.8	−34.3	3.27 ± 0.23	2.99 ± 0.21
3	L	Superior frontal	4.768	62	−11	14	45.6	2.59 ± 0.16	2.54 ± 0.23
1	R	Paracentral	5.153	166	10.1	−15.5	48.9	2.44 ± 0.12	2.42 ± 0.21
2	R	Parahippocampal	4.928	59	25.2	−20.9	−27.3	3.20 ± 0.31	3.03 ± 0.22
3	R	Lateral orbitofrontal	4.671	50	30.4	28.9	−2.4	2.72 ± 0.12	2.62 ± 0.23
4	R	Posterior cingulate	3.926	17	5.1	−12.5	39.4	2.65 ± 0.13	2.64 ± 0.24

Cluster no.		Structures in area	Max t statistic	Size (mm²)	TalX	TalY	TalZ	Thickness (mm), mean ± SD
Cluster no.		Structures in area	Max t statistic	Size (mm²)	TalX	TalY	TalZ	Baseline ACLF	Post ACLF
1	L	Lateral orbitofrontal	−2.745	577	−29	50.8	−10.9	2.08 ± 0.15	2.33 ± 0.15
2	L	Rostral middle frontal	−2.632	93	−37.1	43.4	0.3	1.95 ± 0.12	2.12 ± 0.11
3	L	Rostral middle frontal	−2.244	25	−38.6	26.5	35.6	2.25 ± 0.10	2.35 ± 0.09
4	L	Rostral middle frontal	−2.210	43	−33.9	32.4	29.5	2.06 ± 0.12	2.24 ± 0.14
5	L	Superior frontal	−2.204	59	−8.1	62.2	16.9	2.25 ± 0.16	2.50 ± 0.17
6	L	Lateral orbitofrontal	−2.013	4	−35.9	25.6	−17.7	2.31 ± 0.18	2.51 ± 0.12
1	R	Entorhinal	−3.97	185	21	−11.2	−29.2	2.89 ± 0.22	3.37 ± 0.22
2	R	Superior frontal	−2.313	71	8.3	58.1	26.5	2.29 ± 0.18	2.53 ± 0.15
3	R	Rostral middle frontal	−2.232	74	19.7	57	17.6	2.06 ± 0.21	2.30 ± 0.12
4	R	Lateral orbitofrontal	−2.086	36	17.1	39.4	−18.9	2.04 ± 0.14	2.26 ± 0.20
5	R	Pars triangularis	−2.0108	2	54.3	25.6	10.1	2.30 ± 0.14	2.50 ± 0.17

Each area consists of adjacent voxels showing a significant group difference; some brain structures have more than one area of change. The magnitude of the peak (t statistic) in each area and its Tailarach coordinates (a standardized common brain space) are listed, together with the size (in normalized space) and the mean and SD of the cortical thickness for control and post recovery ACLF group. And baseline and post recovery ACLF group
CT cortical thickness, L left, R right

ISSN: 1479-5876