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Table 2 Surface areas of significantly reduced cortical thickness in baseline ACLF over control from both hemispheres

From: Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

Cluster no. Structures in area Max t-statistic Size (mm2) TalX TalY TalZ Cortical thickness (Mean ± SD)
Control Baseline
1 L Rostral middle frontal 6.48 965 −42.7 29.1 30.1 2.45 ± 0.10 2.17 ± 0.11
2 L Superior frontal 4.55 935 −9.6 63.2 13.7 2.66 ± 0.24 2.24 ± 0.16
3 L Pars triangularis 4.52 1251 −50.8 24.9 5.9 2.58 ± 0.13 2.29 ± 0.12
4 L Posterior cingulate 4.41 162 −10.9 −2.6 39.8 2.60 ± 0.13 2.35 ± 0.17
5 L Inferior temporal 4.31 536 −55.5 −33.2 −16.6 2.76 ± 0.17 2.48 ± 0.11
6 L Lateral orbitofrontal 4.16 284 −12.4 42.6 −21.9 2.16 ± 0.17 1.89 ± 0.11
7 L Caudal middle frontal 3.95 264 −42 2.4 48.5 2.65 ± 0.23 2.32 ± 0.13
8 L Precentral 3.67 229 −55.1 −3.2 38.8 2.69 ± 0.14 2.46 ± 0.10
9 L Entorhinal 3.59 75 −19.9 −14.2 −28.5 3.16 ± 0.18 2.80 ± 0.20
10 L Superior temporal 3.51 137 −63.5 −30.1 7.3 2.68 ± 0.15 2.40 ± 0.15
11 L Inferior temporal 3.51 454 −41.2 −0.2 −36.8 3.30 ± 0.25 2.81 ± 0.26
12 L Middle temporal 2.99 390 −51.2 −20.2 −14.8 2.64 ± 0.25 2.33 ± 0.13
13 L Supramarginal 2.80 35 −60 −26.8 21.2 2.54 ± 0.17 2.38 ± 0.13
14 L Pars opercularis 2.76 29 −34.7 12.7 24.4 2.22 ± 0.17 2.01 ± 0.10
15 L Supramarginal 2.63 11 −52.2 −47 43.9 2.63 ± 0.18 2.38 ± 0.16
16 L Pars opercularis 2.59 15 −44.2 5.2 7.8 2.67 ± 0.15 2.49 ± 0.15
17 L Middle temporal 2.59 18 −56.4 −7.9 −27.8 3.08 ± 0.24 2.78 ± 0.17
18 L Lingual −2.58 21 −7.4 −68.3 −0.3 1.71 ± 0.13 1.97 ± 0.23
19 L Inferior parietal 2.54 5 −39.7 −68.5 35.1 2.45 ± 0.12 2.23 ± 0.17
1 R Parahippocampal 5.74 191 23.3 −23.6 −23.2 2.93 ± 0.17 2.48 ± 0.16
2 R Rostral middle frontal 5.29 537 35.9 45.7 21.6 2.27 ± 0.06 2.01 ± 0.12
3 R Pars triangularis 5.19 888 54.3 26.1 9.1 2.63 ± 0.09 2.32 ± 0.14
4 R Lateral orbitofrontal 4.96 402 15.5 35.5 −24 2.24 ± 0.17 1.94 ± 0.11
5 R Superior frontal 4.45 270 17.7 38.7 42.2 2.54 ± 0.08 2.27 ± 0.14
6 R Pars orbitalis 3.92 728 40.2 51 −7.2 2.53 ± 0.16 2.13 ± 0.22
7 R Posterior cingulate 3.84 94 9.7 −1.6 41.2 2.65 ± 0.18 2.36 ± 0.12
8 R Postcentral 3.44 121 61.5 −9.7 30.5 2.46 ± 0.14 2.17 ± 0.16
9 R Precuneus 3.44 88 7.4 −60.7 57.3 2.37 ± 0.16 2.11 ± 0.17
10 R Rostral middle frontal 3.45 725 23.1 54.6 21.1 2.30 ± 0.16 2.05 ± 0.15
11 R Superior temporal 3.41 263 51.6 −18.1 −5.4 2.77 ± 0.21 2.47 ± 0.15
12 R Precentral 2.91 60 50.4 −0.1 41.4 2.72 ± 0.22 2.41 ± 0.17
13 R Superior frontal 2.90 65 7.9 37.4 42.5 2.81 ± 0.19 2.51 ± 0.21
14 R Caudal middle frontal 2.83 21 31 13.9 47.8 2.46 ± 0.12 2.25 ± 0.16
15 R Superior temporal 2.73 29 49.8 6.3 −16.9 3.22 ± 0.33 2.74 ± 0.32
  1. Each area consists of adjacent voxels showing a significant group difference; some brain structures have more than one area of change. The magnitude of the peak (t statistic) in each area and its Tailarach coordinates (a standardized common brain space) are listed, together with the size (in normalized space) and the mean and SD of the cortical thickness for the control and baseline ACLF groups
  2. L left, R right
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Journal of Translational Medicine

ISSN: 1479-5876

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