Fig. 4

PEP-1-MsrA ameliorated oxidation and inflammation in the plasma and the liver of apoE^−/− mice. The 21-week-old apoE^−/− mice were fed a Western diet and intraperitoneally injected with PBS, MsrA or PEP-1-MsrA proteins for 12 weeks. a, b Plasma PON1 and SOD activities were determined, n = 8–10. c Plasma MCP-1 level was detected by ELISA, n = 10. d MsrA and PON1 levels in the liver were determined by Western blot. e PON1 mRNA levels in mice liver were measured by qPCR. f The mRNA levels of TNFα and IL-6 in mice liver were measured by qPCR. All tests were analyses of three independent experiments (n = 4–5). *P < 0.05, **P < 0.01 vs control group, ^Δ P < 0.05, ^ΔΔ P < 0.01 vs MsrA group