Table 1 Subject characteristics for miRNA array
|  | Control | T1 ≥ 470 | T1 < 470 |
|---|---|---|---|
n | 4 | 4 | 4 |
Gender (m/f) | 4/0 | 3/1 | 2/2 |
Age (years) | 42 ± 16.3 | 49.5 ± 5.5 | 58.3 ± 9.5 |
Height (cm) | 175.8 ± 8.6 | 172.8 ± 5.9 | 165.5 ± 11.1 |
Weight (kg) | 77.8 ± 4.1 | 83.5 ± 20.3 | 70 ± 6.7 |
Body mass index (kg/m2) | 25.4 ± 3.5 | 27.8 ± 5.8 | 25.8 ± 4 |
Family history of HCM (%) | NA | 50Â % | 75Â % |
Resting heart beat (beats/min) | 66.8 ± 9.5 | 69 ± 11.6 | 60.5 ± 7.9 |
Systolic blood pressure (mmHg) | 120.4 ± 10.2 | 129.5 ± 16.6 | 125.3 ± 11.6 |
Diastolic blood pressure (mmHg) | 73 ± 9.8 | 77.3 ± 10.8 | 70 ± 10.9 |
eGFR (mL/min/1.75 m2) | 87.8 ± 6.5 | 79 ± 10.7 | 77.3 ± 15 |
Medications | |||
 β-blockers | NA | 25 % | 75 % |
 Calcium channel blockers | NA | 25 % | 25 % |
 Angiotensin convert enzyme inhibitor | NA | 0 % | 0 % |
 Angiotensin receptor blockers | NA | 50 % | 0 %†|
Echocardiography | |||
 Left atrial volume indexed, ml/m2 | 34.2 ± 10.2 | 43.1 ± 10.4 | 56.9 ± 21.3 |
 E/A ratio | 1.53 ± 0.48 | 1.16 ± 0.44 | 1.38 ± 0.51 |
 Deceleration time (ms) | 158.5 ± 15.6 | 226.8 ± 44.8* | 200.3 ± 25.2 |
 Septal e′ (cm/s) | 10 ± 3.6 | 6.2 ± 2.1 | 6 ± 2.2 |
 Lateral e′ (cm/s) | 13.3 ± 2.3 | 7.9 ± 3* | 7.8 ± 2.9* |
 Mean e′ (cm/s) | 11.7 ± 2.9 | 7 ± 2.5* | 6.9 ± 2.3* |
 Septal E/e′ | 8.6 ± 3.4 | 11.1 ± 2.8 | 18.9 ± 8.8 |
 Lateral E/e′ | 6 ± 1.3 | 9 ± 2.9 | 14.1 ± 5.9* |
 Mean E/e′ | 7.3 ± 2.3 | 10.1 ± 2.9 | 16.5 ± 7.2* |
 Resting LVOT gradient (mmHg) | 4.5 ± 1.1 | 47.8 ± 68.7 | 51.6 ± 60 |
CMR | |||
 T1 times (ms), excluding LGE | 578.5 ± 42 | 561.5 ± 31.9 | 440.3 ± 30.3***,††|
 T1 times (ms), including LGE | 578.5 ± 42 | 550.9 ± 44.6 | 435.3 ± 45.5***,††|
 T1 times (ms, corrected values) | 567.6 ± 50.6 | 549.7 ± 34.7 | 422.4 ± 26.6***,††|
 Blood T1 times (ms) | 296.0 ± 5.3 | 300.8 ± 31.7 | 302.3 ± 18.8 |
 Septal thickness (mm) | 7.75 ± 0.96 | 18 ± 3.6** | 19 ± 3.2** |
 Lateral wall thickness (mm) | 7.5 ± 1 | 8.5 ± 1.3 | 8.3 ± 1.7 |
 Septal/lateral wall thickness | 1.04 ± 0.07 | 2.12 ± 0.35** | 2.35 ± 0.44** |
 LV mass index (g/BSA) | 55.1 ± 8.9 | 90.6 ± 30.4 | 94.0 ± 28.3 |
 LV ejection fraction (%) | 57.5 ± 6.1 | 69 ± 2.9 | 67 ± 15.5 |
 Presence of LGE (%) | NA | 75 % | 75 % |
 Quantity of LGE (% of LV) mass | NA | 2.9 ± 4 | 10.1 ± 12.2 |