Fig. 4
From: Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules
a Demonstrates the structure of the biomolecule and structure of VEGFR1 along with the docking site of the biomolecule on VEGFR1 sequence. b Shows multiple alignment of VEGFR1, 2, 3 along with marked amino acid sequence for the biomolecules luteolin, lupeol and lectin. Multiple sequence alignments of vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3): amino acid residues with similar nature are highlighted with same colour. Further, active site residues of VEGFR1 identified upon docking with retinoic acid (V841, V892, C1018, C1039), luteolin (E878, V891, V892, C1018, I1019,H1020, R1021, I1038, D1040), Lupeol (L833, V841, A859, K861, E878, V909, Y911, C912,G915, L1029, D1040) and lectin (D807, V841, K861,E878, I881, I885, H887, V891, V892,L1013, R1016, C1018, I1019, H1020, R1021, I1038, C1039, D1040, F1041, G1042, L1043) are marked with pink, dark blue, dark green and purple colour arrows respectively