Fig. 1

Anatomical image is showing a subcutaneous EL4 tumor in a mouse model. Chemical-shift imaging for ¹³C-glucose and ¹³C-lactate from the same animal was obtained 15 s after intravenous injection of 0.4 mL of 200 mM hyperpolarized glucose. ¹³C-lactate signal demonstrates generation of lactate through anaerobic glycosylation. This material was reproduced with permission from the Nature Publishing Group and Rodrigues et al. [77]