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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: STAT1 modification improves therapeutic effects of interferons on lung cancer cells

Fig. 5

Overexpressing STAT1-CC enhances IFN-γ or IFN-β induced apoptosis of lung cancer cells. Apoptosis was detected by Annexin V apoptosis detection Kit and analysed by flow cytometry. a Flow cytometry results were demonstrated from control, EGFP-, STAT1-, and STAT1-CC-expressing SPC-A-1 cells treated with IFN-γ 10,000 U/ml or IFN-β 10,000 U/ml for 96 h. b Quantitative analysis of the population of SPC-A-1 apoptotic cells. c Control, EGFP-, STAT1-, and STAT1-CC-expressing H1299 cells were treated with IFN-γ 1000 U/ml or IFN-β 1000 U/ml for 48 h. Quantitative analysis of the population of apoptotic cells in Three independent experiments were conducted and data are shown as mean ± SEM. **P < 0.01

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