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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: STAT1 modification improves therapeutic effects of interferons on lung cancer cells

Fig. 1

Lentiviral vector constructs for STAT1 and STAT1-CC. Diagram illustrates the target sequence of the sites for double-cysteine mutations in the SH2 domain of STAT1 and subsequent orientation into STAT1 and then into lentiviral vectors expressing EGFP with intervening IRES. The abbreviation of STAT1 domains: ND N-terminal domain, CCD coiled coil domain, DBD DNA-binding domain, LD linker domain, SH2D SH2 domain, TD transactivation domain

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