Fig. 7
Forced expression of Fra-1 or miR-195-inhibitor partially rescued miR-195-dependent suppression of tumorous behavior. a DU145 and PC3 cells were co-transfected with either miR-195-inhibitor or Inhibitor-NC oligos with siFra-1. Transwell assays were conducted and quantified (*P < 0.05). b Forced expression of Fra-1 abrogated cell motility impairment by miR-195 (representative migration and invasion results at ×100 were shown). Quantitative analysis revealed a significant increase in cell migration and invasion after Fra-1 re-expression. c Western blot analysis was performed to confirm the re-expression of Fra-1 and other related proteins