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Table 1 Patients characteristics, efficacy of step-up FMT strategy and medication before and after step-up FMT

From: Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis

Pt Age (year) Sex Duration (year) Location/severity Medication before step-up FMT FMT strategy Clinical response to FMT Medication after step-up FMT Free of steroid
Status of steroids usage (equivalent to prednisone, mg/day) Combination therapy
1 11 M 1 Left sided/S3 Maintenance dose 10 mg/day Mesalamine 3.0 g/day One FMT No response Prednisone 10 mg/day as maintenance and then switch to anti-TNF therapy for half a year No
2 48 F 1 Extensive/S3 Relapse after withdrawal of prednisone to 10 mg/day AZA 50 mg/day One FMT Short-term improvement and flared within 1 month Prednisone 15 mg/day as maintenance No
3 47 M 9 Extensive/S3 Relapse after withdrawal of prednisone AZA 50 mg/day One FMT Short-term improvement and flared within 1 month Prednisone 10 mg/day as maintenance No
4 19 F 4 Extensive/S3 Maintenance dose 10 mg/day Mesalamine 3.0 g/day One FMT No response Switch to anti-TNF at the first week No
5 20 F 6 Extensive/S3 Maintenance dose 20 mg/day for 3 years before FMT Mesalamine 3.0 g/day One FMT Short-term improvement and flared within 1 month Prednisone 20 mg/day as maintenance No
6 32 M 1 Extensive/S3 Maintenance dose 10 mg/day Mesalamine 4.0 g/day One FMT S3 to S1 Mesalamine 3.0 g/day as for 4 months Yes
7 32 M 8 Extensive/S3 Serious flare with shock and diarrhea after withdrawal of prednisone to 20 mg/day Mesalamine 4.0 g/day Two FMTs S3 to S2 Scheduled prednisone and then switch to Mesalamine 3.0 g/day for 4 months Yes
8 34 M 4 Extensive/S3 Relapse immediately after withdrawal of prednisone TCM One FMT S3 to S2 Mesalamine 3.0 g/day for 5 months Yes
9 23 M 2 Extensive/S3 Maintenance dose 10 mg/day for 7 months Mesalamine 4.0 g/day Two FMTs S3 to S2 Mesalamine 3.0 g/day for 6 months Yes
10 38 M 8 Extensive/S3 Maintenance dose 10 mg/day for more than 2 years AZA 50 mg/day One FMT S3 to S0 Mesalamine 3.0 g/day for 9 months Yes
11 39 M 7 Left sided/S2 Relapse immediately after withdraw of prednisone to 15 mg/day – One FMT S2 to S0 Mesalamine 3.0 g/day for 18 months Yes
12 37 F 3 Proctitis/S2 Maintenance dose 35 mg/day for 31 months Mesalamine 4.0 g/day One FMT S2 to S0 Mesalamine 3.0 g/day for 11 months Yes
13 35 M 1 Extensive/S3 Maintenance dose 20 mg/day for 3 years and 2 months Mesalamine 4.0 g/day Two FMTs S3 to S0 Follow by scheduled prednisones and then switch to Mesalamine 3.0 g/day as maintenance without relapse for 12 months Yes
14 27 M 2 Extensive/S3 Relapse after withdrawal of prednisone to 15 mg/day – Two FMTs Short-term improvement but flared soon afterward. Long-term remission of multiple skin infections Prednisone 15 mg/day as maintenance No
15 33 M 6 Left sided/S3 Maintenance dose 10 mg/day for 2 years – One FMT S3 to S2, but lost to follow-up – –
  1. Pt patient, M male, F female, AZA azathioprine, TCM traditional Chinese medicine
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Journal of Translational Medicine

ISSN: 1479-5876

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