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Table 1 Patients characteristics, efficacy of step-up FMT strategy and medication before and after step-up FMT

From: Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis

Pt

Age (year)

Sex

Duration (year)

Location/severity

Medication before step-up FMT

FMT strategy

Clinical response to FMT

Medication after step-up FMT

Free of steroid

Status of steroids usage (equivalent to prednisone, mg/day)

Combination therapy

1

11

M

1

Left sided/S3

Maintenance dose 10 mg/day

Mesalamine 3.0 g/day

One FMT

No response

Prednisone 10 mg/day as maintenance and then switch to anti-TNF therapy for half a year

No

2

48

F

1

Extensive/S3

Relapse after withdrawal of prednisone to 10 mg/day

AZA 50 mg/day

One FMT

Short-term improvement and flared within 1 month

Prednisone 15 mg/day as maintenance

No

3

47

M

9

Extensive/S3

Relapse after withdrawal of prednisone

AZA 50 mg/day

One FMT

Short-term improvement and flared within 1 month

Prednisone 10 mg/day as maintenance

No

4

19

F

4

Extensive/S3

Maintenance dose 10 mg/day

Mesalamine 3.0 g/day

One FMT

No response

Switch to anti-TNF at the first week

No

5

20

F

6

Extensive/S3

Maintenance dose 20 mg/day for 3 years before FMT

Mesalamine 3.0 g/day

One FMT

Short-term improvement and flared within 1 month

Prednisone 20 mg/day as maintenance

No

6

32

M

1

Extensive/S3

Maintenance dose 10 mg/day

Mesalamine 4.0 g/day

One FMT

S3 to S1

Mesalamine 3.0 g/day as for 4 months

Yes

7

32

M

8

Extensive/S3

Serious flare with shock and diarrhea after withdrawal of prednisone to 20 mg/day

Mesalamine 4.0 g/day

Two FMTs

S3 to S2

Scheduled prednisone and then switch to Mesalamine 3.0 g/day for 4 months

Yes

8

34

M

4

Extensive/S3

Relapse immediately after withdrawal of prednisone

TCM

One FMT

S3 to S2

Mesalamine 3.0 g/day for 5 months

Yes

9

23

M

2

Extensive/S3

Maintenance dose 10 mg/day for 7 months

Mesalamine 4.0 g/day

Two FMTs

S3 to S2

Mesalamine 3.0 g/day for 6 months

Yes

10

38

M

8

Extensive/S3

Maintenance dose 10 mg/day for more than 2 years

AZA 50 mg/day

One FMT

S3 to S0

Mesalamine 3.0 g/day for 9 months

Yes

11

39

M

7

Left sided/S2

Relapse immediately after withdraw of prednisone to 15 mg/day

One FMT

S2 to S0

Mesalamine 3.0 g/day for 18 months

Yes

12

37

F

3

Proctitis/S2

Maintenance dose 35 mg/day for 31 months

Mesalamine 4.0 g/day

One FMT

S2 to S0

Mesalamine 3.0 g/day for 11 months

Yes

13

35

M

1

Extensive/S3

Maintenance dose 20 mg/day for 3 years and 2 months

Mesalamine 4.0 g/day

Two FMTs

S3 to S0

Follow by scheduled prednisones and then switch to Mesalamine 3.0 g/day as maintenance without relapse for 12 months

Yes

14

27

M

2

Extensive/S3

Relapse after withdrawal of prednisone to 15 mg/day

Two FMTs

Short-term improvement but flared soon afterward. Long-term remission of multiple skin infections

Prednisone 15 mg/day as maintenance

No

15

33

M

6

Left sided/S3

Maintenance dose 10 mg/day for 2 years

One FMT

S3 to S2, but lost to follow-up

  1. Pt patient, M male, F female, AZA azathioprine, TCM traditional Chinese medicine