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Table 1 Grading criteria for bone marrow fibrosis [29]

From: Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis

Grading Description
0 Scattered linear reticulin with no intersections corresponding to normal bone marrow
1 Loose network of reticulin with many intersections, especially in perivascular areas
2 Diffuse and dense increase in reticulin with extensive intersections, occasionally with only focal bundles of collagen and/or focal osteosclerosis
3 Diffuse and dense increase in reticulin with extensive intersections with coarse bundles of collagen, often associated with significant osteosclerosis
  1. Bone marrow fibrosis is assessed in areas of haematopoietic cellularity