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Table 4 Zonal measurement of cartilage thickness and measurement and scoring of the osteophytes on histology slides (safranin O) at the medial tibial plateau

From: Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis

Parameter Unit Area SHAM MMT
Cartilage thickness μm z1 536.15 ± 18.78 1035.51 ± 34.62**
z2 916.96 ± 21.14 182.76 ± 20.05**
z3 1092.5 ± 23.13 1016.00 ± 25.81
Damage score (1–5) score z1–z3 0.2 ± 0.04 4.3 ± 1.62**
Cartilage matrix loss width μm 0 % 307.44 ± 145.73 4586.24 ± 846.11**
50 % 126.53 ± 82.22 2631.76 ± 350.87**
100 % 46.36 ± 145.73 1843.15 ± 304.20**
Total cartilage degeneration width μm z1–z3 312.46 ± 35.26 4965.55 ± 930.87**
Significant cartilage degeneration width μm z1–z3 6.32 ± 10.50 1987.53 ± 962.81**
Osteophyte size μm z1 26.42 ± 15.81 480.19 ± 62.33** (large)
  1. p < 0.05 or ** p < 0.001 relative to sham rats