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Table 3 Zonal analysis of subchondral bone and articular cartilage covering the medial tibial plateau

From: Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis

Parameter Unit Zone SHAM MMT % difference
Bone volume mm3 z1 0.37 ± 0.03 0.46 ± 0.05** 24.4↑
z2 0.42 ± 0.02 0.49 ± 0.04** 16.7↑
z3 0.45 ± 0.04 0.47 ± 0.04 4.4↑
z1 1003.79 ± 14.52 980.10 ± 16.80 2.4↔
Bone mineral density g/cm2 z2 1020.19 ± 17.80 1031.94 ± 7.56 1.1↔
z3 984.21 ± 24.53 978.70 ± 11.51 0.6↔
z1 0.12 ± 0.02 0.19 ± 0.06* 58.3↑
Cartilage volume mm3 z2 0.20 ± 0.02 0.11 ± 0.04** 45.0↓
z3 0.19 ± 0.04 0.23 ± 0.04* 21.1↑
z1 0.14 ± 0.02 0.18 ± 0.06* 28.6↑
Cartilage thickness mm z2 0.23 ± 0.02 0.15 ± 0.04** 34.8↓
z3 0.23 ± 0.04 0.20 ± 0.03 12.1↓
Osteophyte   z1 None Large  
  1. The subchondral bone and articular cartilage were divided into 3 zones; Zone 1 (z1) was placed on the outside of the medial edge of the joint, and Zone 3 (z3) was placed on the inside (central) of the tibial plateau, adjacent to the central collateral ligaments. There were also large osteophytes present in Zone 1 in the MMT rats
  2. p < 0.05 or ** p < 0.001 relative to sham rats