Table 1 Analysis of hnRNPD protein expression and correlation with clinicopathological parameters
Clinicopathological features | Total cases N | Nuclear n | Positivity (%) | p value | Odd’s ratio | (95 % CI) |
|---|---|---|---|---|---|---|
Normal | 106 | 20 | (18.9) | Â | Â | Â |
Dysplasia | 44 | 24 | (54.5) | <0.001 a | 5.4 | (2.5–11.7) |
 Mild | 31 | 18 | (58.0) |  |  |  |
 Moderate | 10 | 4 | (40) |  |  |  |
 Severe | 3 | 1 | (33.3) |  |  |  |
OSCCs | 183 | 120 | (65.6) | <0.001 b | 8.1 | (4.6–14.5) |
Age (median 45 years) (range 15–85 years) | ||||||
 <45 | 64 | 47 | (73.4) |  |  |  |
 ≥45 | 119 | 73 | (61.3) | 0.10 | 0.5 | (0.2–1.1) |
Gender | ||||||
 Male | 149 | 102 | (68.5) |  |  |  |
 Female | 34 | 18 | (52.9) | 0.08 | 1.9 | (0.9–4.1) |
Differentiation | ||||||
 WDSCC | 89 | 57 | (64.0) |  |  |  |
 MDSCC | 86 | 58 | (67.4) |  |  |  |
 PDSCC | 8 | 5 | (62.5) | 0.87 |  | – |
Tumor size | ||||||
 T1 + T2 | 65 | 34 | (52.3) |  |  |  |
 T3 + T4 | 118 | 86 | (72.9) | 0.005 | 2.4 | (1.3–4.6) |
Tumor stage | ||||||
 I + II | 31 | 15 | (48.4) |  |  |  |
 III + IV | 152 | 105 | (69.1) | 0.02 | 2.3 | (1.0–5.2) |
Nodal status | ||||||
 N0 | 61 | 37 | (60.7) |  |  |  |
 N1–4 | 122 | 83 | (68.0) | 0.32 | 1.3 | (0.7–2.6) |
Habits* | ||||||
 Non consumer | 33 | 27 | (69.7) |  |  |  |
 Tobacco consumer | 150 | 97 | (64.7) | 0.58 | 0.7 | (0.3–1.7) |