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Table 1 Analysis of hnRNPD protein expression and correlation with clinicopathological parameters

From: Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer

Clinicopathological features Total cases N Nuclear n Positivity (%) p value Odd’s ratio (95 % CI)
Normal 106 20 (18.9)    
Dysplasia 44 24 (54.5) <0.001 a 5.4 (2.5–11.7)
 Mild 31 18 (58.0)    
 Moderate 10 4 (40)    
 Severe 3 1 (33.3)    
OSCCs 183 120 (65.6) <0.001 b 8.1 (4.6–14.5)
Age (median 45 years) (range 15–85 years)
 <45 64 47 (73.4)    
 ≥45 119 73 (61.3) 0.10 0.5 (0.2–1.1)
Gender
 Male 149 102 (68.5)    
 Female 34 18 (52.9) 0.08 1.9 (0.9–4.1)
Differentiation
 WDSCC 89 57 (64.0)    
 MDSCC 86 58 (67.4)    
 PDSCC 8 5 (62.5) 0.87  
Tumor size
 T1 + T2 65 34 (52.3)    
 T3 + T4 118 86 (72.9) 0.005 2.4 (1.3–4.6)
Tumor stage
 I + II 31 15 (48.4)    
 III + IV 152 105 (69.1) 0.02 2.3 (1.0–5.2)
Nodal status
 N0 61 37 (60.7)    
 N1–4 122 83 (68.0) 0.32 1.3 (0.7–2.6)
Habits*
 Non consumer 33 27 (69.7)    
 Tobacco consumer 150 97 (64.7) 0.58 0.7 (0.3–1.7)
  1. * Tobacco consumption habits include tobacco chewing and/or smoking of bidi or cigarettes, chewing of betel quid, areca nut or pan masala
  2. aNormal vs. dysplasia
  3. bNormal vs. OSCCs