|
Treatment
|
Rotarod test
|
Open-field test
|
Body temperature
|
|---|
|
First fall (s)
|
Falls
|
Crossing
|
Rearing
|
|---|
|
Vehicle
|
176 ± 21
|
2.3 ± 0.5
|
47 ± 8
|
11 ± 1
|
0.29 ± 0.06
|
|
PCW
|
183 ± 18
|
1.7 ± 0.3
|
54 ± 6
|
9 ± 1
|
0.36 ± 0.06
|
|
AMG9810
|
–
|
–
|
–
|
–
|
1.09 ± 0.12***
|
- Mice were randomly divided into 3 groups: the vehicle (10 ml/kg, p.o.) group, PCW (1.35 g/kg, p.o.) group and AMG9810 (30 μmol/kg, p.o.)-treated group for rotarod test, open-field test or body temperature assessment. Significant differences were not observed in the locomotion or body temprature tests between vehicle and PCW (1.35 g/kg. p.o.) groups, while AMG9810 (30 μmol/kg, p.o.) significantly increased rectal temperature compared to vehicle or PCW (1.34 g/kg. p.o.) groups. Data are expressed as mean ± SEM. (n = 6)
- *** P < 0.001 vs. the vehicle or PCW groups
