Treatment | Rotarod test | Open-field test | Body temperature |
|---|
First fall (s) | Falls | Crossing | Rearing |
|---|
Vehicle | 176 ± 21 | 2.3 ± 0.5 | 47 ± 8 | 11 ± 1 | 0.29 ± 0.06 |
PCW | 183 ± 18 | 1.7 ± 0.3 | 54 ± 6 | 9 ± 1 | 0.36 ± 0.06 |
AMG9810 | – | – | – | – | 1.09 ± 0.12*** |
- Mice were randomly divided into 3 groups: the vehicle (10 ml/kg, p.o.) group, PCW (1.35 g/kg, p.o.) group and AMG9810 (30 μmol/kg, p.o.)-treated group for rotarod test, open-field test or body temperature assessment. Significant differences were not observed in the locomotion or body temprature tests between vehicle and PCW (1.35 g/kg. p.o.) groups, while AMG9810 (30 μmol/kg, p.o.) significantly increased rectal temperature compared to vehicle or PCW (1.34 g/kg. p.o.) groups. Data are expressed as mean ± SEM. (n = 6)
- *** P < 0.001 vs. the vehicle or PCW groups
