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Table 3 The effects of PCW on locomotion and body temprature of mice 1 h after administration

From: Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel

Treatment Rotarod test Open-field test Body temperature
First fall (s) Falls Crossing Rearing
Vehicle 176 ± 21 2.3 ± 0.5 47 ± 8 11 ± 1 0.29 ± 0.06
PCW 183 ± 18 1.7 ± 0.3 54 ± 6 9 ± 1 0.36 ± 0.06
AMG9810 1.09 ± 0.12***
  1. Mice were randomly divided into 3 groups: the vehicle (10 ml/kg, p.o.) group, PCW (1.35 g/kg, p.o.) group and AMG9810 (30 μmol/kg, p.o.)-treated group for rotarod test, open-field test or body temperature assessment. Significant differences were not observed in the locomotion or body temprature tests between vehicle and PCW (1.35 g/kg. p.o.) groups, while AMG9810 (30 μmol/kg, p.o.) significantly increased rectal temperature compared to vehicle or PCW (1.34 g/kg. p.o.) groups. Data are expressed as mean ± SEM. (n = 6)
  2. *** P < 0.001 vs. the vehicle or PCW groups