Fig. 6

Antinociceptive effects of PCW co-treated with Nor-BNI in capsaicin tests. Nor-BNI (13.6 μmol/kg, s.c., 15 min before) or AMG9810 (30 mg/kg, i.p., 30 min before) were pretreated to mice. Then PCW (1.35 g/kg, p.o.) or distilled water (10 ml/kg, p.o.) were administered, and capsaicin tests were performed 0.5 (for i.p. administration) or 1 h (for p.o. administration) later. Immediately after capsaicin injection, the nociceptive responses were evaluated as the time spent licking the injected paw during 5 min (a), and the mechanical (15 min after capsaicin injection) (b), thermal (15 min after capsaicin injection) (c) hypersensitivities were also assessed. Data are represented as the mean ± SEM. (n = 6). ^### P < 0.001 vs. the control group; **P < 0.01 and ***P < 0.001 vs. the capsaicin group, respectively