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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel

Fig. 5

Antinociceptive effects of PCW in CFA-induced TRPV1−/− and TRPV1+/+ mice. Baselines of PWT and PWL were tested in TRPV1−/− and TRPV1+/+ mice before and 48 h after CFA treatment in the right hind paw (a) and (b) (n = 6). Then, mice were orally administrated by syringe feeding with PCW (1.35 g/kg) or vehicle (10 ml/kg) once. Mechanical hypersensitivity of the injured paw was assessed by the sensitivity to the application of von Frey hairs 0, 0.5, 1, 2, 3, 4 h, post-PCW administration, respectively (c) (n = 8). Data are represented as the mean ± SEM. (n = 6). ### P < 0.001 vs. the baseline; *P < 0.05 and ***P < 0.001 vs. the CFA group, respectively; & P < 0.05 and && P < 0.01 indicate TRPV1−/− vs. the TRPV1+/+ group, respectively

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