TY - JOUR AU - Wang, Chao AU - Sun, Danni AU - Liu, Chunfang AU - Zhu, Chunyan AU - Jing, Xianghong AU - Chen, Shuping AU - Liu, Cuiling AU - Zhi, Kai AU - Xu, Tengfei AU - Wang, Hui AU - Liu, Junling AU - Xu, Ying AU - Liu, Zhiqiang AU - Lin, Na PY - 2015 DA - 2015/08/30 TI - Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel JO - Journal of Translational Medicine SP - 284 VL - 13 IS - 1 AB - Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinically. However, its action on chronic inflammatory pain has not been clarified. Here, we investigated the antinociceptive effect of PCW in complete freund’s adjuvant (CFA)-induced mice and its possible mechanisms associated with opioid system and TRPV1 ion channel. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-015-0636-4 DO - 10.1186/s12967-015-0636-4 ID - Wang2015 ER -