Fig. 3

The hypertrophic changes of cultured cardiomyocytes over-expression apelin and controls. The hypertrophic changes of cells were indicated by the cellular protein content and cellular surfaces sizes. a Cultured cardiomyocytes had similar cellular protein contents between control and apelin gene transfection cells. However, when treated with Ang II, the cells over-expressing apelin had significantly lower protein contents. b The typical images of cellular size before and after Ang II treatment in cultured cardiomyocytes over-expression apelin and controls. Cardiomyocytes had similar cellular sizes between control and apelin gene transfected cells. After Ang II treatment, the cells over-expressing apelin had significantly smaller size than controls