Table 3 Maximum toxicity per patient
Toxicity | Cohort 1 (n = 5) | Cohort 2 (n = 4) | Cohort 3 (n = 3) | All cohort (n = 12) | ||||
|---|---|---|---|---|---|---|---|---|
Grade | Grade | Grade | Grade | |||||
1–2 | 3 | 1–2 | 3 | 1–2 | 3 | 1–2 | 3 | |
Hematological | ||||||||
 Neutropenia | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
 Lymphopenia | 3 | 1 | 3 | 0 | 0 | 0 | 6 | 1 |
 Anemia | 3 | 1 | 3 | 1 | 2 | 0 | 8 | 2 |
 Thrombocytopenia | 2 | 1 | 1 | 0 | 0 | 0 | 3 | 1 |
 Elevated AST | 2 | 0 | 1 | 0 | 0 | 0 | 3 | 0 |
 Elevated ALT | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
 Elevated total billirubin | 0 | 1 | 2 | 0 | 1 | 0 | 3 | 1 |
Non-hematological | ||||||||
 Fatigue | 2 | 0 | 3 | 0 | 3 | 0 | 8 | 0 |
 Fever | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
 Anorexia | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 |
 Nausea | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 |
 Diarrhea | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 |
 Constipation | 1 | 0 | 2 | 0 | 0 | 0 | 3 | 0 |