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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres

Fig. 5

JAK2 inhibitor SAR317461 induced cell autophagy and cell autophagy inhibitors enhanced cell death induced by SAR317461. a Stable U251 cell line expressed GFP-LC3 induced GFP clusters with 1 µM SAR317461 treatment. b Cell viability decreased dramatically after SAR317461 and cell autophagy inhibitors. There were three replicates per condition and for the starvation control cells were cultured in media without FBS. Statistical differences between cell viability obtained in cells treated with SAR317461 with or without autophagy inhibitors were determined using a 2-tailed, paired t test. Bars indicate standard error of the mean and p values of less than 0.05 indicated statistical significance and are denoted by asterisks above the columns. c Photomicrographs showing cell morphology and density with various treatments.

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