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Table 1 Relationship between miR-101 expression levels and clinicopathological parameters for the present LSCC cohort

From: MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8

Clinicopathological parameters

N (No. of patients)

Level of miR-101 expression (T/N ratio)a

P value

Patient gender

  

0.776

 Male

56

0.208 ± 0.056

 

 Female

24

0.212 ± 0.059

 

T classification

  

0.015

 T1–2

40

0.225 ± 0.054

 

 T3–4

40

0.194 ± 0.055

 

Lymph node metastasis

  

0.044

 Negative

45

0.221 ± 0.051

 

 Positive

35

0.195 ± 0.06

 

Differentiation

  

0.096

 Well

54

0.202 ± 0.053

 

 Moderately/poorly

26

0.225 ± 0.061

 

Patient age

  

0.051

 ≥60 years

48

0.212 ± 0.050

 

 <60 years

32

0.206 ± 0.065

 

Clinical stage

  

0.004

 I–II

38

0.228 ± 0.054

 

 III–IV

42

0.192 ± 0.053

 

Tobacco exposure

  

0.638

 Smoker

60

0.208 ± 0.060

 

 Nonsmoker

20

0.215 ± 0.045

 

miR-101 levels

  

<0.01

 Low

40

0.166 ± 0.030

 

 High

40

0.253 ± 0.039

 
  1. aTumour/normal (T/N) ratio: fold change in miR-101 expression in LSCC tissue to the corresponding adjacent normal tissue. MiR-101 expression was measured by real-time PCR and was normalized to an external control (human U6 gene). Values were quantified using the 2−ΔΔCt method. Values are presented as the mean ± SD.
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Journal of Translational Medicine

ISSN: 1479-5876

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