EVs/exosomes characterization and signature in patients with alcoholic hepatitis (AH) versus controls and receiver operating characteristic (ROC) curves. a Number of EVs was measured in the plasma of patients with alcoholic hepatitis and healthy individuals using a Nanoparticle tracking analysis (Nanosight). The EVs with diameters less than 150 nm were defined as exosomes and EVs with diameter more than 150 nm were defined as microvesicles. b–d Levels of miRNA-122, miRNA-192 and miRNA-30 were quantified in plasma-derived EVs isolated from alcoholic hepatitis individuals and healthy controls by TaqMan qPCR assay. e, f Curve of receiver operating characteristic (ROC) analysis constructed for differentially expressed miRNA-30a, miRNA-192, and for discriminating patients with alcoholic hepatitis versus controls (*p < 0.05).