Interaction of TCF7 and IL-4. TCF7 promotes Th2 cell differentiation through transcriptional activation of GATA3. Th2 cells produce IL-4, which stimulates STAT6 and inhibits dominant negative TCF7, which represses the transcription of TCF7 target genes. Therefore, through inhibition of dn-TCF7, the process of Th2 cell differentiation is promoted. TCF7 transcription factor 7, dnTCF7 dominant negative transcription factor 7, GATA3 GATA binding protein 3, IL-4 interleukin 4, STAT6 signal transducer and activator of transcription 6.