Table 3 Renal protein levels of cytokines and TNF-α-related signaling in the ApoE/ACE2 DKO mice
Gene name | Description | Folds up- or down-regulation (vs. ApoEKO mice) | P value |
|---|---|---|---|
TNF-α | Tumor necrosis factor | 5.16 | 0.023 |
CD30 ligand | TNFSF8; TNF ligand superfamily member 8 | 1.92 | 0.012 |
CD30 | TNFRSF8; TNF receptor superfamily member 8 | 1.15 | 0.540 |
Fas ligand | TNFSF6; TNF ligand superfamily member 6 | 2.74 | 0.025 |
TNFRSF1A | TNF RI; TNF receptor superfamily member 1A | 2.10 | 0.020 |
TNFRSF1B | TNF RII; TNF receptor superfamily member 1B | 1.09 | 0.665 |
GITR | TNFRSF18; TNF receptor superfamily member 18 | 2.28 | 0.026 |
OGN | Osteoprotegerin; TNF receptor superfamily member 11B | 2.27 | 0.024 |
TRANCE | TNFSF11;TNF ligand superfamily member 11 | 2.15 | 0.023 |
TROY | TNFRSF19; TNF receptor superfamily member 19 | 1.19 | 0.456 |
RENTES | CCL5; C–C motif chemokine 5 | 2.33 | 0.006 |
ICAM-1 | Intercellular adhesion molecule 1 | 1.79 | 0.014 |
VCAM-1 | Vascular cell adhesion protein 1 | 1.14 | 0.730 |
IL-1α | Interleukin-1 alpha | 1.47 | 0.205 |
IL-1β | Interleukin-1 beta | 2.69 | 0.025 |
IL-2 | Interleukin-2 | 1.80 | 0.101 |
IL-3 | Interleukin-3 | 2.34 | 0.034 |
IL-4 | Interleukin-4 | −1.74 | 0.024 |
IL-5 | Interleukin-5 | 1.41 | 0.567 |
IL-6 | Interleukin-6 | 2.61 | 0.033 |
IL-7 | Interleukin-7 | 1.37 | 0.293 |
IL-9 | Interleukin-9 | 1.62 | 0.220 |
IL-10 | Interleukin-10 | −1.19 | 0.065 |
IL-2p40/p70 | Interleukin-12 subunit beta | 1.71 | 0.154 |
IL-12 p70 | Interleukin-12 subunit alpha | 1.20 | 0.539 |
IL-13 | Interleukin-13 | 2.43 | 0.023 |
IL-15 | Interleukin-15 | 1.38 | 0.183 |
IL-17A | Interleukin-17A | 3.11 | 0.010 |
IL-17RB | Interleukin-17 receptor B | 1.22 | 0.301 |