| WTC | ApoEKO | ACE2KO | DKO | ApoEKO + rhACE2 | ApoEKO + Ang II | ApoEKO + Ang II +rhACE2 |
---|---|---|---|---|---|---|---|
n | 8 | 7 | 8 | 7 | 7 | 6 | 5 |
SBP (mm Hg) | 100.8 ± 3.5 | 103.1 ± 2.4 | 118.3 ± 3.1** | 124.5 ± 3.3**# | 104.5 ± 3.0 | 153.2 ± 4.2## | 127.2 ± 3.1ϕ |
BW (g) | 25.1 ± 1.2 | 25.9 ± 1.0 | 24.7 ± 0.8 | 23.5 ± 1.2 | 26.1 ± 1.1 | 24.6 ± 1.4 | 25.3 ± 1.5 |
BUN (mmol/L) | 6.4 ± 0.3 | 9.3 ± 0.4* | 9.4 ± 0.7* | 13.9 ± 0.9**## | 8.9 ± 0.6 | 15.6 ± 0.7## | 10.5 ± 0.6ϕ |
Cr (μmol/L) | 11.1 ± 0.8 | 18.4 ± 1.5* | 19.8 ± 1.9* | 40.4 ± 4.0**## | 10.3 ± 1.0# | 52.4 ± 7.2## | 25.8 ± 1.7ϕ |
TG (mmol/L) | 0.59 ± 0.05 | 1.14 ± 0.07* | 0.73 ± 0.08 | 1.23 ± 0.13* | 1.06 ± 0.11 | 1.23 ± 0.16 | 1.15 ± 0.13 |
CHO (mmol/L) | 1.48 ± 0.11 | 6.46 ± 0.34** | 1.61 ± 0.15 | 7.31 ± 0.60** | 6.4 ± 0.4 | 8.57 ± 0.43 | 8.25 ± 0.5 |
Plasma Ang II (pg/mL) | 38.6 ± 1.8 | 43.5 ± 2.1 | 69.0 ± 3.8* | 75.3 ± 4.6**# | 40.9 ± 2.1 | 302.9 ± 15.9## | 172.2 ± 14.4ϕ |