Skip to main content

Table 2 The general data in mice

From: Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling

 

WTC

ApoEKO

ACE2KO

DKO

ApoEKO + rhACE2

ApoEKO + Ang II

ApoEKO + Ang II +rhACE2

n

8

7

8

7

7

6

5

SBP (mm Hg)

100.8 ± 3.5

103.1 ± 2.4

118.3 ± 3.1**

124.5 ± 3.3**#

104.5 ± 3.0

153.2 ± 4.2##

127.2 ± 3.1ϕ

BW (g)

25.1 ± 1.2

25.9 ± 1.0

24.7 ± 0.8

23.5 ± 1.2

26.1 ± 1.1

24.6 ± 1.4

25.3 ± 1.5

BUN (mmol/L)

6.4 ± 0.3

9.3 ± 0.4*

9.4 ± 0.7*

13.9 ± 0.9**##

8.9 ± 0.6

15.6 ± 0.7##

10.5 ± 0.6ϕ

Cr (μmol/L)

11.1 ± 0.8

18.4 ± 1.5*

19.8 ± 1.9*

40.4 ± 4.0**##

10.3 ± 1.0#

52.4 ± 7.2##

25.8 ± 1.7ϕ

TG (mmol/L)

0.59 ± 0.05

1.14 ± 0.07*

0.73 ± 0.08

1.23 ± 0.13*

1.06 ± 0.11

1.23 ± 0.16

1.15 ± 0.13

CHO (mmol/L)

1.48 ± 0.11

6.46 ± 0.34**

1.61 ± 0.15

7.31 ± 0.60**

6.4 ± 0.4

8.57 ± 0.43

8.25 ± 0.5

Plasma Ang II (pg/mL)

38.6 ± 1.8

43.5 ± 2.1

69.0 ± 3.8*

75.3 ± 4.6**#

40.9 ± 2.1

302.9 ± 15.9##

172.2 ± 14.4ϕ

  1. SBP systolic blood pressure, BW body weight, BUN blood urea nitrogen, Cr creatinine, TG triacylglycerol, CHO cholesterol, Ang II angiotensin II, KO knockout, WTC wild-type control mice, ApoE apolipoprotein E, DKO ApoE/ACE2 double knockout mice, ACE2 angiotensin-converting enzyme 2, rhACE2 recombinant human ACE2.
  2. Results are presented as mean ± SEM. * P < 0.05, ** P < 0.01 compared with WTC group; # P < 0.05, ## P < 0.01 compared with ApoEKO control group; ϕ P < 0.05 compared with ApoEKO + Ang II group.