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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling

Fig. 4

ACE2 deficiency led to increases in renal inflammation in the ApoE/ACE2 DKO mice. The real-time PCR (a–f) and Western blot analyses (g–j) revealed the mRNA or protein levels of the inflammatory cytokines in mice kidneys, including TNFα, TNFRSF1A, TNFRSF1B, IL-1β, IL-6, and IL-17A. n = 5–6. GAPDH or β-actin was used as an endogenous control. RE relative expression, WTC wild-type control, ApoE apolipoprotein E, KO knockout, DKO the ApoE/ACE2 double knockout, TNFα tumor necrosis factor-α, IL interleukin. Please see other abbreviations in Table 3. *P < 0.05; **P < 0.01 compared with WT control group; # P < 0.05 compared with ApoEKO group.

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