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Table 2 Overall lung inflammation and fibrosis score in an animal model of bleomycin-induced lung injury

From: Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis

Group Saline vehicle control Bleomycin control Bleomycin + esomeprazole low-dose prophylactic Bleomycin + esomeprazole high-dose prophylactic
No. of animals examined 6 10 14 15
No. of without lung lesions 6 0 5 3
Chronic inflammation (average score) 0.0 2.2 1.4 1.6
Fibrosis (average score) 0.0 2.9 1.6 1.6
  1. Animals were prophylactically treated with two doses of esomeprazole (30 or 300 mg/kg/day) or vehicle for up to 28 days. Subsequently, the lung tissues were harvested, stained and scored for inflammation and fibrosis.