Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis

Table 2 Overall lung inflammation and fibrosis score in an animal model of bleomycin-induced lung injury

Group	Saline vehicle control	Bleomycin control	Bleomycin + esomeprazole low-dose prophylactic	Bleomycin + esomeprazole high-dose prophylactic
No. of animals examined	6	10	14	15
No. of without lung lesions	6	0	5	3
Chronic inflammation (average score)	0.0	2.2	1.4	1.6
Fibrosis (average score)	0.0	2.9	1.6	1.6

Animals were prophylactically treated with two doses of esomeprazole (30 or 300 mg/kg/day) or vehicle for up to 28 days. Subsequently, the lung tissues were harvested, stained and scored for inflammation and fibrosis.

ISSN: 1479-5876