|
Group
|
Saline vehicle control
|
Bleomycin control
|
Bleomycin + esomeprazole low-dose prophylactic
|
Bleomycin + esomeprazole high-dose prophylactic
|
|---|
|
No. of animals examined
|
6
|
10
|
14
|
15
|
|
No. of without lung lesions
|
6
|
0
|
5
|
3
|
|
Chronic inflammation (average score)
|
0.0
|
2.2
|
1.4
|
1.6
|
|
Fibrosis (average score)
|
0.0
|
2.9
|
1.6
|
1.6
|
- Animals were prophylactically treated with two doses of esomeprazole (30 or 300 mg/kg/day) or vehicle for up to 28 days. Subsequently, the lung tissues were harvested, stained and scored for inflammation and fibrosis.
