Fig. 4

Esomeprazole regulates bleomycin-induced changes in gene expression in various lung cell types. In a–c suppression of pro-inflammatory/pro-fibrotic markers in primary epithelial (a), endothelial (b) and fibroblasts (c) is shown. d–f demonstrates increased expression of the cytoprotective enzyme HO1 by esomeprazole in each of these cell types. g shows upregulation of the lung repair associated gene chitinase-3-like 1 (CHI3L1) in primary lung epithelial cells. Data is Mean ± SEM from duplicate experiments. *p < 0.05 compared to vehicle.