Fig. 3
The PPI esomeprazole regulates ionizing radiation-induced changes in gene expression in primary lung epithelial cells cultured in 3D matrix. In a inhibition of the spike in the pro-inflammatory cytokines TNF-α, NFκB and IL-6 is shown. b shows downregulation of the proapoptotic protein p53 and c shows the upregulation of the antioxidant gene HO1 by esomeprazole. Data is Mean ± SEM from duplicate experiments. *p < 0.05 compared to vehicle.