Skip to main content
Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Combined Trabectedin and anti-PD1 antibody produces a synergistic antitumor effect in a murine model of ovarian cancer

Fig. 4

Expression profiling of immune-associated genes in tumors from treated mice. a Mice (6 mice per group) inoculated i.p. with 1 × 106 ID8 cells 10 day earlier were treated as described in Fig. 1a. Seven days after treatment commencement, tumors were excised and their RNA were extracted for the analysis of immune-associated gene expression by quantitative RT-PCR. a The expression of Th1-related molecules CXCR3, CXCL9, CXCL10, T-bet, IL-12p40 and IFN-γ. b, c The expression of genes relating with TAM/MDSC and Treg recruitment/accumuation and function, including CCL2, CXCL12, CD14, M-CSFR, Arginase-1, iNOS, IL-1β, IL-6, IL-10, TGF-β, VEGF and FoxP3. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page