Fig. 8

Glucose catabolism (a) and steady state levels of labeled (M + 3) lactate (b) in plasma from controls (light blue), trauma (yellow) or hemorrhagic shock (orange) rats after 35 min from injection of labeled carbon (iLC). In A, heavy labeled glucose (M + 6) detected at 35 min from no treatment (control), trauma or hemorrhage was normalized against the first time point after iLC (considered 100% of the spiked in value). In b, values were normalized against the average of steady state levels of labeled lactate detected in controls, and expressed as fold change variations of heavy lactate levels detected in plasma from trauma and hemorrhagic shock rats. Hemorrhagic shock promoted glucose hypercatabolism, while trauma alone reduced fluxes of glucose consumption in comparison to untreated control rats.